John Lachin
John Lachin
D.Sc.
Emeritus Research Professor of Biostatistics and Bioinformatics, and of Statistics
Emeriti
School: Milken Institute School of Public Health
Department: Biostatistics and Bioinformatics
Contact:
Biostatistics Center , 6110 Executive Blvd, Rockville, MD 20852
Dr. Lachin is Research Professor of Biostatistics and Bioinformatics, and of Statistics, formerly with tenure 1987-2014; and former Director of The Biostatistics Center from 1988-2000 and 2010-12. Dr. Lachin was the founding director of the GWU graduate program in Biostatistics and Epidemiology and mentored 15 doctoral students in Statistics, Biostatistics or Epidemiology. Dr. Lachin no longer teaches.
Dr. Lachin is a Fellow of the American Statistical Association, the Royal Statistical Society, and the Society for Clinical Trials for which he also served as President.
Dr. Lachin authored 5 books including Biostatistical Methods (Wiley, Second Edition, 2011) and Randomization in Clinical Trials (co-author, Wiley, Second Edition, 2016) that won the American Association of Publishers' award for "Outstanding professional and scholarly title of 2002 in mathematics and science." He has also authored 90 methodological papers (67 peer-reviewed), and over 260 peer-reviewed scientific papers. As of September 29, 2019 his h-Index was 80, meaning that 80 of his peer reviewed authored papers had been cited at least 80 times. His papers had received 79,135 citations.
Dr. Lachin is currently principal investigator of Biostatistical Research Center for the study of the Epidemiology of Diabetes Interventions and Complications (EDIC), and is Co-principal investigator for the Glycemia Reduction Approaches for Diabetes Effectiveness: A Comparative Effectiveness Study (GRADE), both funded by the National Institute of Diabetes, Digestive and Kidney Diseases. In 1994, he was a co-recipient of the American Diabetes Association's Charles H. Best Medal for Distinguished Service in the Cause of Diabetes, which was awarded to the Diabetes Control and Complications Trial (DCCT) Research Group.
His recent co-authored medical papers include the demonstration that intensive treatment of type 1 diabetes leading to near normal levels of glucose can reduce mortality and the progression or retinal and renal microvascular complications during the EDIC study, the phenomenon of metabolic memory that was first reported in a landmark paper in the New England Journal of Medicine (NEJM) in 2000 for which Dr. Lachin was the lead author. He is an author of 18 papers in the NEJM.
Recent methodological publications include description of the Wei-Lachin multivariate one-directional test for multiple outcomes; and its application to composite outcomes.
Additional information about Dr. Lachin is available on the Biostatistic Center's web site.
EXPERTISE:
Biostatistics
Epidemiology
EDUCATION:
Doctor of Science (Biostatistics), University of Pittsburgh, 1972 Bachelor of Science, Tulane University, 1965
TEACHING:
Introduction to Biostatistics (Statistics 1127), lecturer
Data Analysis (Statistics 6210), developer and lecturer
Design of Medical Studies (formerly Statistics 224, now PH 6247), developer and lecturer;
Biostatistical Methods (formerly Statistics 225, now PH 6266), developer and lecturer
Advanced Biostatistical Methods (formerly Statistics 226), lecturer
Survival Analysis (Statistics 6227), developer and lecturer.
Dr. Lachin no longer teaches.
COMMUNITY SERVICE:
Professor Lachin has served on the Data and Safety Monitoring Board of numerous clinical trials, including ones sponsored by the National Heart Lung and Blood Institute, the National Institute of Diabetes, Digest and Kidney Diseases and the pharmaceutical industry. He has served on the editorial board of Controlled Clinical Trials and as a board member and committee chairman at the Society for Clinical Trials, prior to assuming the presidency.
INSTITUTES AND CENTERS:
Dr. Lachin in the Principal Investigator on two grants from the National Institute of Diabetes, Digestive and Kidney Diseases: • Glycemia Reduction Approaches for Diabetes Effectiveness: A Comparative Effectiveness Study (GRADE) 07/2017 – 07/2022, P.I., Coordinating Center, NIDDK Cooperative Agreement 1 U01 DK-098246, $115,406,642. • Epidemiology of Diabetes Intervention and Complications: 7/2017 - 04/2022, P.I., Coordinating Center, NIDDK Grant U01-DK094176-02, $15,998,739. Dr. Lachin's recent publications have focused on applications of the Wei-Lachin multivariate test and analyses to the assessment of multiple outcomes in a comparative effectiveness study, and its application to the analysis of composite outcomes. Dr. Lachin was also a co-author of reports from the EDIC study on various long-term benefits of a period of intensive diabetes management to reduce glucose levels including reductions in cardiovascular disease and mortality, and reports on patient characteristics (risk factors) that determine the risk of advanced microvascular outcomes and cardiovascular disease.