Jordan R. Kuiper

Jordan R. Kuiper

Assistant Professor

Full-time Faculty

School: Milken Institute School of Public Health

Department: Environmental and Occupational Health

Contact:

Email: Jordan R. Kuiper

Milken Institute School of Public Health 950 New Hampshire Avenue, NW, 4th Floor Washington DC 20052

Dr. Jordan Kuiper is an environmental and prenatal/perinatal/pediatric epidemiologist whose research primarily focuses on children’s environmental health. Specifically, his work aims to characterize environmental exposures to legacy and emerging chemicals of concern across the early life-course, and further elucidate their implications on various child health outcomes. He is particularly interested in exposures to endocrine-disrupting chemicals, such as phthalates, organophosphate esters, bisphenols, and per- and polyfluoroalkyl substances. Most recently, his research has focused on children in the neonatal intensive care unit and identifying drivers of adverse outcomes among this heterogenous and highly vulnerable population.

In addition to children’s environmental health, Dr. Kuiper has extensive expertise in molecular epidemiology, including the use of biomarkers in epidemiologic research, as well as advanced biostatistical and epidemiological methods, including missing data, selection bias, exposure mixtures, causal inference, and latent variable modeling.

More from Jordan Kuiper

PubMed

Expertise

EXPERTISE:
Biostatistics
Chemical exposures
Children’s Environmental Health
Endocrine Disrupting Chemicals
Environmental Epidemiology
Environmental and Occupational Health
Epidemiologic Methods
Maternal and Child Health

EDUCATION:

PhD, Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health (2019)
MS, Cell and Molecular Biology, Saint Cloud State University
BES, Biology, Saint Cloud State University

TEACHING:

PubH 6121: Environmental and Occupational Epidemiology (3 credits) - 2023 – current

INSTITUTES AND CENTERS:

Affiliated Faculty, GW Climate and Health Institute, 2023 – present
Affiliated Faculty, GW Jacobs Institute of Women’s Health
Affiliated Faculty, GW Maternal and Child Health Center of Excellence

Research

RESEARCH:

Dr. Kuiper’s research seeks to improve the lives of our most vulnerable population: children. Specifically, his work spans across general populations of children as well as specific populations of critically ill children, understanding etiologic risk factors for various illnesses/diseases, and ways to mitigate adverse health effects.

Dr. Kuiper’s current research interests include:

Health impacts of chemical exposures. We are exposed to an array of toxic chemicals every day, including endocrine disrupting chemicals. We are conducting research to characterize exposures and understand their health implications, particularly for exposures incurred during pregnancy and in early life. We are also characterizing exposures in hospital settings from commonly used medical equipment, devices, and support fluids, specifically in the context of neonates with congenital heart defects, and whether such exposures negatively impact postoperative outcomes and later neurodevelopment.
Precision medicine. With artificial intelligence and machine learning it is now possible to combine a wide array of data to better understand disease etiology, inform clinical decision-making, and improve outcomes for critically ill patients. We are working to understand the risk factors for hypoxic-ischemic encephalopathy, a severe form of brain injury at birth, as well as biomarkers that are predictive of adverse outcomes. Additionally, we are exploring the extent to which differences in neurodevelopmental outcomes are driven by social determinants of health.

Publications

PUBLICATIONS:

Up-to-date list of publications

Oh J, Buckley JP, Li X, Gachigi KK, Kannan K, Lyu W, Ames JL, et al. 2023. Associations of organophosphate ester flame retardant exposures during pregnancy with gestational duration and fetal growth: The Environmental influences on Child Health Outcomes (ECHO) Program. Environ Health Perspect [in press].

Fleury ES, Kuiper JR, Buckley JP, Papandonatos GD, Cecil KM, Chen A, Eaton CB, Kalkwarf HJ, Lanphear BP, Yolton K, Braun JM. Evaluating the association between longitudinal exposure to a PFAS mixture and adolescent cardiometabolic risk in the HOME Study. Environ Epidemiol [accepted].

Liu SH, Chen Y, Kuiper JR, Ho E, Buckley JP, Feuerstahler L. 2023. Applying latent variable models to estimate cumulative exposure burden to chemical mixtures and identify latent exposure subgroups: A critical review and future directions. Stat Biosci [in press].

Kuiper JR, Liu SH, Lanphear BP, Calafat AM, Cecil KM, Xu Y, Yolton K, Kalkwarf HJ, Chen A, Braun JM, Buckley JP. 2023. Estimating effects of longitudinal and cumulative exposure to PFAS mixtures on early adolescent body composition. Am J Epidemiol, [in press].

Liu Y, Gairola R, Kuiper JR, Papandonatos GD, Kelsey KT, Langevin SM, Buckley JP, Chen A, Lanphear BP, Cecil KM, Yolton K, Braun JM. 2023. Lifetime postnatal exposure to perfluoroalkyl substance mixture and DNA methylation at twelve years of age. Environ Sci Technol Lett, [in press]. doi:10.1021/acs.estlett.3c00410.

Louis LM, Buckley JP, Kuiper JR, Meeker J, Hansel NN, Diette G, McCormack MC, Quiros-Alcala L. 2023. Exposures to organophosphate esters and respiratory morbidity among school-aged children with asthma. Environ Sci Technol, 57(16):6435-6443.

Kuiper JR, Shudi P, Lanphear BP, Calafat AM, Chen A, Cecil KM, Xu Y, Yolton K, Kalkwarf HJ, Braun JM, Buckley JP. 2023. Associations of maternal gestational urinary environmental phenols concentrations with bone mineral density among 12-year-old children in the HOME Study. Int J Hyg Environ Health, 248:114104. PMID: 36525700.

Etzel TM, Kuiper JR, Wang X, Mueller NT, Calafat AM, Cecil KM, Chen A, Lanphear BP, Yolton K, Kalkwarf HJ, Braun JM, Buckley JP. 2022. Associations of early life phthalate exposures with adolescent lipid levels and insulin resistance: The HOME Study. Int J Hyg Environ Health, 248:114102. doi:10.1016/j.ijheh.2022.114102.

Camerota M, McGowan E, Aschner J, Stroustrup A, Karagas M, Conradt E, Crowell S, et al.,. 2022. Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO program. Pediat Res, doi:10.1038/s41390-023-02540-2.

Choi G, Buckley JP, Kuiper JR, Keil AP. 2022. Log-transformation of independent variables: must we? Epidemiol, 33(6):843-853. PMID: 36220581.

Kuiper JR, Vuong AM, Lanphear BP, Calafat AM, Ospina M, Cecil KM, Xu Y, Yolton K, Kalkwarf HJ, Braun JM, Chen A, Buckley JP. 2022. Early life organophosphate ester exposures and bone health at age 12 years: The Health Outcomes and Measures of the Environment (HOME) Study. Sci Tot Environ [Epub Ahead of Print]. doi:10.1016/j.scitotenv.2022.158246.

Liu SH, Kuiper JR, Chen Y, Feuerstahler L, Teresi J, Buckley JP. 2022. Quantifying latent exposure burden to chemical mixtures using item response theory. Environ Health Perspect, 130(11):11700. doi: 10.1289/EHP10125.

Choi G, Kuiper JR, Bennett D, Barrett E, Bastain T, Breton C, Chinthakindi S, et al. 2022. Exposure to melamine and its derivatives and aromatic amines among pregnant women in the United States: The ECHO Program. Environ Int, doi:10.1016/j.chemosphere.2022.135599.

Buckley JP, Kuiper JR, Bennett D, Barrett E, Bastain T, Breton C, Chinthakindi S, et al. 2022. Exposure to contemporary and emerging chemicals in commerce among pregnant women in the United States: The Environmental Influences on Child Health Outcomes (ECHO) Program. J Environ Sci Technol, doi: 10.1021/acs.est.1c08942.

Etzel T, Braun JM, Kuiper JR, Calafat AM, Cecil KM, Chen A, Lanphear BP, Yolton K, Kalkwarf HJ, Buckley JP. 2022. Gestational and childhood phthalate exposures and adolescent body composition: The HOME Study. Environ Res, 212(Pt B):113320.

Louis LM, Quiros-Alcala L, Kuiper JR, Diette G, Hansel N, McCormack M, Meeker, Buckley JP. 2022. Variability and predictors of urinary organophosphate ester concentrations among urban school-aged children. Environ Res, 25(212 Pt A):113192.

Kuiper JR, O’Brien KM, Welch BM, Barrett ES, Nguyen RHN, Sathyanarayana S, Milne GL, Swan SH, Ferguson KK, Buckley JP. 2022. Combining urinary biomarker data from studies with different measures of urinary dilution. Epidemiology, doi: 10.1097/EDE.0000000000001496.

Kuiper JR, Braun JM, Calafat AM, Lanphear BP, Cecil KM, Chen A, Xu Y, Yolton K, Kalkwarf HJ, Buckley JP. 2021. Associations of pregnancy phthalate concentrations and their mixture with early adolescent bone mineral content and density: The Health Outcomes and Measures of the Environment (HOME) study. Bone. doi: 10.1016/j.bone.2021.116251

Buckley JP, Kuiper JR, Lanphear BP, Calafat AM, Chen A, Xu Y, Yolton K, Kalkwarf HJ, Braun JM. 2021. Associations of maternal serum perfluoroalkyl substances concentrations with early adolescent bone mineral content and density: The Health Outcomes and Measures of the Environment (HOME) Study. Environ Health Perspect, 129(9):97011. doi: 10.1289/EHP9424.

Kuiper JR, O’Brien M, Ferguson KK, Buckley JP. 2021. Urinary specific gravity measures in the U.S. population: Implications for the adjustment of non-persistent chemical urinary biomarker data. Environ Int. [Epub Ahead of Print].doi:10.1016/j.envint.2021.106656.

Soliai MM, Sundaresan AS, Morin A, Hirsch AG, Stanhope C, Kuiper JR, Schwartz BS, Ober C, Pinto J. 2021. Two-stage genome-wide associations study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk. Int Forum Allergy Rhinol, 11(4):814-817.

Kuiper JR, Stapleton H, Wills-Karp M, Wang X, Burd I, Buckley JP. 2020. Predictors and reproducibility of urinary organophosphate ester metabolite concentrations during pregnancy and associations with birth outcomes in an urban population. Environmental Health, 19(1):55.

Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz, BS. 2020. A new approach to categorization of radiologic inflammation in chronic rhinosinusitis. PLoS ONE, 15(6): e0235432.

Hirsch AG, Nordberg C, Bandeen-Roche K, Tan BK, Schleimer RP, Kern RC, Sundaresan AS, Pinto JM, Kennedy TL, Kuiper JR, Schwartz BS. 2020. Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample. Allergy, 75(4):911-920.

Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz BS. 2019. Workplace indirect cost impacts of nasal and sinus symptoms and related conditions. JOEM, 61(8):e333-e339.

Cole M, Bandeen-Roche K, Hirsch AG, Kuiper JR, Sundaresan AS, Tan BK, Schleimer RP, Kern RC, Schwartz BS. 2018. Longitudinal evaluation of clustering of chronic sinonasal and related symptoms using exploratory factor analysis. Allergy, 73(8):1715-1723.

Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Schleimer RP, Kern RC, Stewart WF, Schwartz BS. 2018. Prevalence, severity, and risk factors for acute exacerbations of nasal and sinus symptoms by chronic rhinosinusitis status. Allergy, 73(6):1244-1253.

Kuiper JR, Moran M, Cetkovic-Cvrlje M. 2016. Exposure to polychlorinated biphenyl-153 decreases incidence of autoimmune type 1 diabetes in non-obese diabetic mice. J Immunotoxicol, 13(6):850-860.