Biostatistics and Epidemiology Consulting Service (BECS)
COVID-19 Notice: Groups involved with study design, conduct, statistical analysis, and reporting at GWU and Children’s National Hospital are coordinating to provide priority response to COVID-19 studies. For more information, click here.
The Biostatistics and Epidemiology Consulting Service (BECS) provides biostatistical and epidemiologic support to improve the quality of health-related research conducted at the George Washington University and by affiliated research groups. We provide support through consultations, extended collaborative relationships, communication about best practices, and broad-based services in research design, statistical analysis, data management, and dissemination of findings.
The priority services of the BECS are pre-award consultations and analysis:
- Pre-award consultation on biostatistical methods, sample size selection, and study design for health-related grant proposals
- Assistance with pre-award statistical analysis of preliminary data to support a grant application
There is no fee for these pre-award services, although it is possible that charge-back mechanisms may be developed in the future.
For post-award services and analyses, typically the consulting biostatistician or epidemiologist would be included in the grant application as a co-investigator, and receive a negotiated percent effort to support their ongoing participation in the study should the grant application be successful. The BECS will assist investigators to develop appropriate scope of work and budget justifications as well as standard descriptions of available resources and facilities.
Non-grant related services and consultations are also available subject to faculty availability.
Available Services
The BECS provides assistance to health researchers directly as well as through connected services: the DC-CFAR and the CTSI-CN. The services available depend on your institution, role, and area of research as summarized in the table below. Click on the links for more information and to request services.
Your Research Area |
||||
Your Role |
HIV/AIDS |
Clinical or Translational |
Other Heath-Related |
Non-Health Related |
GW employee with faculty appointment (any school)* |
NA |
|||
MFA employee with GW faculty appointment OR resident OR fellow |
NA |
|||
Faculty at Children’s National* |
NA |
|||
GW PhD student - dissertation |
||||
GW other graduate or undergraduate student |
||||
Not at GW or Children’s National |
Generally not currently available |
*Applies to GW staff working with faculty as well.
**Individual departments sometimes offer statistical consultation services to their students for student research.
Academic Commons: Statistical consultations through Gelman Library.
BECS: Biostatistics and Epidemiology Consulting Service.
BECS Quick Clinic: provides free one hour consultations.
CTSI-CN: Clinical and Translational Science Institute at Children's National; the BECS and Children’s Hospital Division of Biostatistics jointly provide statistical consulting services to investigators located at either GWU or Children’s Hospital.
DBM: Division of Biostatistics and Methodology at Children's Research Institute.
DC-CFAR: DC Center for AIDS Research; supports HIV/AIDS researchers from any of the 8 participating organizations within the District of Columbia; support is coordinated through the BECS.
MFA Statistical Services: The GWU MFA provides statistical support to GW MFA-based investigators. Contact Rich Amdur at ramdur@mfa.gwu.edu for more information.
Request BECS Services
Grant applications
Please email becs@gwu.edu. Include your name, the PI's name (if someone other than you), department, study/project title, and a brief explanation of what you'd like to discuss.
Quick Questions
For health-related statistical and data management questions that can typically be answered within an hour, please schedule an appointment to attend the BECS Quick Clinic.
Support for basic science research (not clinical translational)
Please email becs@gwu.edu. Include your name, the PI's name (if someone other than you), study/project title, and a brief explanation of what you'd like to discuss.
Support for all other research projects
For all other research projects, please complete a SPARC request through the CTSI-CN website. Once we receive the request, we will contact you to clarify details of the support needed, and the project will be assigned to one of our consultants. Click here for instructions.
Not sure what you need? Email us at becs@gwu.edu
BECS Quick Clinic
The BECS Quick Clinic is a free resource for GW-based faculty, medical residents and fellows, and staff working with GW faculty. Now the clinic is also available to GW PhD and DrPH students who have statistical questions connected with their dissertations on health topics. The purpose of the Quick Clinic is to handle health-related statistical and data management questions that can typically be answered within a one-hour session. If you are not sure whether your question can be answered quickly, feel free to attend the clinic anyway. If the answer requires more time, we can advise you on next steps. Here are examples of typical questions that might be answered within a session:
- Based on a medical record review, I would like to compare the profiles of patients who received 1 of 2 treatments. What significance tests should I use?
- My manuscript was conditionally accepted for publication provided that I do a Wilcoxon Rank Sum test to compare 2 groups. How do I do this test?
- What sample size do I need to conduct a study comparing 2 groups?
- I am a research assistant helping a faculty member analyze their data using SAS. The results do not make sense to me. Can you help me understand whether there is an error in my programming?
The clinics are available by appointment during the fall and spring semesters. To see available times and schedule an appointment, click on the link below.
Note: If you are planning to write a grant application, or if you are certain that you will need more than a one hour consultation, instead of the Quick Clinic, you will need to use one of the other service request options here.
Resources
Research Resources
REDCap: The Research Electronic Data Capture (REDCap) application allows users to build and manage online surveys and databases quickly and securely. It is the database platform of choice in all CTSA awarded institutions and for other institutions across the globe. There is no charge for current Children’s National and George Washington University (GW) faculty, staff, sponsored students, and sponsored affiliates conducting clinical and translational research.
CTSPedia: CTSPedia was created as a national effort to collect wisdom, tools, educational materials, and other items useful for clinical and translational researchers and to provide timely and useful advice to clinical and translational researchers with specific problems.
Statistical Software
R Software: R is a free software environment for statistical computing and graphics. It compiles and runs on a wide variety of UNIX platforms, Windows, and MacOS. An additional resource for R users to assist with programming, creating graphics, and understanding output is: DataCamp.
Past Seminars
The seminars listed below were sponsored by the BECS or selected by the BECS for their relevance to good practices in health research. Links to slides and/or webinar recordings are included where available.
The Joint GW-CNHS Biostatistics, Epidemiology, and Research Design (BERD) Tutorial Series
- October 18, 2019: Sensitivity Analyses in Observational Research, Scott Quinlan, PhD
In this 50-minute tutorial, Dr. Quinlan provides an introduction to the uses of sensitivity analyses in public health research. View slides or watch and listen below.
- March 29, 2019: The Use of Instrumental Variables in Observational Research, Scott Quinlan, PhD
Instrumental variables represent a unique approach to address both known and unknown confounders. In this 50-minute tutorial, Dr. Quinlan introduces the basic approach with some examples and discusses the opportunities and challenges of this method for observational research. View slides or watch and listen below.
- October 19, 2018: An Introduction to the Use of Propensity Score Methods, Scott Quinlan, PhD
This 50-minute tutorial provides an introduction to the use of propensity scores methods including how to create, assess, use, and report on propensity scores, as well as how they can contribute to the validity of research and limitations to their appropriate use.
- March 20, 2018: An Introduction to the Challenges and Opportunities of Studying Drug and Vaccine Safety in the Real World, Scott Quinlan, PhD
This 50-minute tutorial provides an introductory review of how drug and vaccine safety issues are identified and studied after FDA approval and initial market entry. The intended audience includes students and researchers with a knowledge of basic statistical methods who are interested in learning more about this growing area of drug and vaccine safety research. Watch below.
- March 10, 2017: Reproducible Analyses, Naji Younes, PhD
Data analyses often stretch over time as results are reviewed and updated. Along the way the data may change as errors are corrected and additional information is obtained. The process of running analyses and repeatedly updating manuscripts or reports can be cumbersome. We'll discuss simple tools to greatly simplify the analyst's work, reduce errors and produce analyses that are easily reproduced and extended by others. This talk focuses on the R language which provide a collection of tools for that purpose, but the ideas can be extended to other languages as well.
- October 3, 2014: REDCap: A Focus on Good Data Management Practices, Adrienne Arrieta, MS
Good data management practices are important to conceptualize before the beginning of data collection in any research study. Establishing how you will conduct, document, organize, manage, preserve, and analyze your data at the beginning of your research project has many benefits. This talk focuses on several good data management techniques and practices and how REDCap (Research Electronic Data Capture) , a free and secure web application for building and managing online surveys and databases, can assist researchers in implementing these techniques to create overall better research and science.
Other Seminars
- March 26, 2018: Evaluation of Public Health Interventions: Recent Developments in Cluster Randomized Trials and Related Designs, Liz Turner, PhD
- October, 2017: The Month of R Series, Naji Younes, PhD
Introduction to using R for analysis of health data.
- October 2, 2015: Pilot Studies and Statistics: A Murky Mix, Sam Simmens, PhD
Pilot studies are nearly universally recommended or required before proceeding with larger confirmatory studies, but the role and value of statistical analyses in these studies is often vague. In this session, Dr. Simmens will review some of the contrasting definitions and recommendations in the literature and lead a discussion of how statistics in pilot or feasibility studies can be useful--or not--for specific kinds of studies.
- June 5, 2015: Strategies for Dealing with Multiple Comparisons, Naji Younes, PhD
Statistical analysis and reports often include many tests of hypotheses. Since each individual test has a chance of yielding a false positive, conducting multiple tests increases the chances of getting spurious results. This talk explores several simple strategies for managing multiple tests, including p-value adjustments, methods that control the false discovery rate and graphical techniques for deriving testing strategies.
Meet Our Team
Leadership |
|
Sam Simmens, PhD (Director) |
Yan Ma, PhD (Associate Director) |
Faculty |
|
Adam Ciarleglio, PhD |
Guoqing Diao, PhD |
Angelo Elmi, PhD |
Heather Hoffman, PhD |
Scott Quinlan, PhD |
Margaret Ulfers, PhD |
Staff |
|
Annette Aldous, MPH |
Morgan Byrne, MPH |
COVID-19 Rapid Response Team
Groups involved with study design, conduct, statistical analysis, and reporting at GWU and Children’s National Hospital are coordinating to provide priority response to COVID-19 studies. Investigators that wish to collaborate, need assistance with planning their COVID-19 studies, or who have statistical analysis needs should contact one of the individuals or groups listed below. For each request, we will review which of our groups has the best fit to the project in terms of resources, skills, and experience. If our existing faculty and staff cannot handle a project, we will try to identify other faculty, staff, and students who may be available, including individuals outside of GW and Children’s National.
Group |
Types of Projects |
How to contact |
GW Biostatistics Center (BSC) |
Diagnostic studies, large multi-center clinical trials, large cohorts |
Dr. Scott Evans (sevans@bsc.gwu.edu) |
Children’s National Hospital Division of Biostatistics and Study Methodology (DBSM) |
All quantitative studies, especially for pediatric populations. |
|
All quantitative health-related studies, especially those with a GW PI. |
Dr. Sam Simmens (simmens@gwu.edu) |
|
|
Clinical and translational research with a statistical component, where the PI is based at either Children’s National or GW. |
|
*To download instructions for submitting a SPARC request, click here: SPARC Request Instructions
For a printable copy of this page, click here: COVID-19 Rapid Response Team for Study Design Analysis and Reporting
Q and A.
- There seems to be overlap among the listed groups in services offered. How do I know which one to contact? There is overlap. For example, the BERD module is jointly staffed by the DBM and BECS. If you are not sure which group to contact, simply contact any of them and the Team will refer you to the group that can best help you.
- How much does this cost? Generally, there is no charge for assistance with a grant application that will be including faculty or staff from one of the groups in the proposed budget. There may be charges for data analysis, data management, and other services.
- Aren’t there other study design and analysis services? There are many additional services available to both GW and Children’s National researchers through the Clinical and Translational Science Institute at Children’s National (CTSI-CN). These include, for example, help with regulatory matters, community engagement, team science, informatics, and “omics” analysis. See ctsicn.org for more information.
- Do you provide similar COVID-19 support to investigators who are not connected to GW or Children’s National? Yes, but all else being equal, GW and Children’s National investigators will have priority.
- I am a faculty member who also has quantitative skills that may benefit COVID-19 investigators. Can I be part of this Team? Yes! Please contact Sam Simmens (simmens@gwu.edu).
Table of typical services provided by each group. Note that there are many other specific services such as electronic health record access that are not listed in this table.
Service |
Statistical Group |
||
|
BSC |
DBSM* |
BECS* |
Grant materials preparation and submission |
x |
x |
x |
Study design |
x |
x |
x |
Biostatistics clinic to answer quick (1 hour) questions |
|
x |
x |
Formulating aims, goals and hypotheses |
x |
x |
x |
Power and sample size calculations |
x |
x |
x |
Development of trial protocols |
x |
|
x |
Development of informed consent |
x |
|
|
Development and maintenance of manuals of operation |
x |
|
|
Design and maintenance of internal and external study websites |
x |
|
|
Case Report Form design |
x |
x |
x |
Web-based data entry system including detailed data editing |
x |
x |
x |
Importing of data from EMRs or laboratories |
x |
x |
|
Daily updated web-based reports such as: tracking, recruitment, visit completion |
x |
|
|
Scheduled reports to a data and safety monitoring committee (DSMB) |
x |
x
|
x |
Data analysis |
x |
x |
x |
Provide some free analysis support through biostatistics practicum graduate students |
|
|
x |
Provide complete data management support using REDCap or OpenClinica© |
|
x
|
|
Publication |
x |
x |
x |
Conference call and online meeting organization and documentation |
x |
x
|
x |
Meeting space for 150 |
x |
|
|
Arrangement of hotel accommodations |
x |
|
|
BSC: GW Biostatistics Center
DBSM: Children’s National Division of Biostatistics and Study Methodology
BECS: GW Biostatistics and Epidemiology Consulting Service
*DBSM and BECS staff the CTSI-CN BERD Module
About
The BECS is embedded within the Milken Institute School of Public Health and receives support from:
The Clinical and Translational Science Institute (CTSI-CN)
The District of Columbia Center for AIDS Research (DC CFAR)