D.C. Cohort Longitudinal HIV Study

Please note the new URL for this information: http://go.gwu.edu/dccohort

The DC Cohort is a longitudinal research project that collects clinical data from approximately 10,000 consenting people living with HIV receiving care at fifteen HIV clinics in the District of Columbia. The DC Cohort is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH).

The primary project goal is to improve the quality of care and treatment of people living with HIV receiving care at large clinics in the District of Columbia by:

  • Linking data from fifteen HIV clinic sites to enable evaluation of HIV care provided in the District of Columbia
  • Monitoring socio-demographic data, clinical status, and treatment regimens of people living with HIV in DC over time
  • Providing clinic sites with routine reports on their patient population that enables them to benchmark and improve their standards of clinical care
  • Contributing to the research of emerging issues in the prevention, treatment, and long-term effects of people living with HIV/AIDS
  • Evaluating the impact of HIV screening and prevention programs in collaboration with the DC Department of Health
  • Creating a resource to facilitate additional HIV research and assist in identifying patients for research studies

The project's scientific objectives are to contribute to the knowledge regarding people living with HIV and their treatment through:

  • Evaluating the outcomes of HIV treatment regimens over time
  • Examining resistance patterns over time in relationship to treatment patterns and patient characteristics
  • Assessing the extent and impact of co-morbidities, such as hepatitis, diabetes, lipidemia, and STDs, on clinical outcomes
  • Advancing research on emerging issues in HIV and its treatment

 

 

 

 

Participant Information

The DC Cohort is open to enrollment for patients receiving care for HIV at one or more of the fifteen participating clinics. In order to join the DC Cohort, patients must be at least 18 years of age. Patients who are minors can also join but they must either be consented by a parent or legal guardian or be teenagers seeking care independently. All patients must be able to understand and sign the informed consent form.

Participant FAQs

What is the DC Cohort?

The DC Cohort is a research project that is collecting health information on people who are receiving HIV care at clinics in the District of Columbia. The information collected will help HIV care providers find out more about HIV and its treatments with the goal of improving HIV care for patients not only in DC, but for patients everywhere.

What is a cohort?

A "cohort" is a group of people who have something in common and who are followed over time. The "cohort" in this research project includes people living with HIV who are getting care in clinics throughout DC.

Which clinics are involved in this research project?

Many of the main HIV care providers in DC are taking part in this research project including:

The DC Department of Health is also taking part in this research project.

Who is paying for and leading this research project?

The DC Cohort is being paid for by the National Institutes of Health (NIH) and is being run by the Department of Epidemiology (DEPI) and the Biostatistics Center (BSC) at The Milken Institute School of Public Health.

What do I have to do to be in this research project?

To be in this research project, you must be getting HIV care from at least one of the DC Cohort participating clinics, give your permission, and sign the consent form allowing researchers to confidentially combine your health information with information from thousands of other persons living with HIV in DC.

You will not have to come to the clinic for extra appointments or visits. You can complete the consent process during your regularly scheduled appointment at the clinic.

Do I have to be part of this research project?

No, you do not have to be part of the DC Cohort if you do not want to be. Nothing about the care that you get at your clinic will change if you are not in this research project. However, we are encouraging all persons living with HIV to be a part of this research project so that we can get a complete picture of HIV care in DC and find better ways to care for all persons living with HIV.

Who will have access to information collected through this research project that could identify me?

Only the staff the clinic at which you are receiving care and at the DC Department of Health who already have this information will have access to it.

How will my information be kept private?

All information will be kept in a safe and secure database.

What if I change my mind after I decide to be a part of the research project?

You can change your mind at any time. If you decide to cancel your permission, you can get a withdrawal form from your clinic and give it to your health care provider. When you cancel, no additional information will be shared about you.

Do I have to pay or will I get paid if I am in this research project?

No, you do not have to pay and will not get paid if you are in this research project.

How can I join this research project?

Someone at the clinic where you are receiving care will ask you to join the DC Cohort. If you want to join, they can tell you more about it and answer any questions you might have. If you decide to join, they will review the consent form with you.

Who do I contact for more information?

For more information, please contact your health care provider at the clinic where you are currently receiving care.

Community Advisory Board

A Community Advisory Board (CAB) has been convened to provide input and guidance on aspects of the study protocols and procedures from the patient perspective. The CAB consists of patient representatives from each clinical site. The purpose and mission of the DC Cohort CAB is to:

  • Provide recommendations and feedback regarding recruitment, retention, and ethical issues associated with the study
  • Share patient perspectives on the study with the Cohort leadership
  • Make recommendations about how to communicate the outcomes of the study to the involved patient populations

Additionally, two members of the CAB serve as ad hoc members of the DC Cohort Executive Committee (EC) and are responsible for communicating and sharing information between the CAB and the EC.

Click here to access the newsletter.

Interested in joining the Community Advisory Board (CAB)?

If you would like to provide community feedback on research related to the care of people living with HIV and you receive care at one of our participating sites, you may be eligible to join the DC Cohort CAB. What is the purpose of the CAB?:

  • To build a relationship between researchers and the community.
  • To receive regular updates on the DC Cohort study progress.
  • To provide community perspectives and guidance on new research.

 

Please contact James Peterson at (202) 994-2852 or jpeterson@gwu.edu. We keep all calls and correspondence confidential. CAB attendees will receive a small stipend.

Investigator Information

DC Cohort investigators are encouraged to develop ideas for analyzing both site-specific and Cohort-wide data. Please see the applicable forms pertaining to data access and publication.

Acknowledgements

The "DC Cohort Investigators" should be acknowledged whenever reference is made to the design and conduct of the study. This standard boilerplate includes the DC Cohort PI, the DC Cohort Senior Co-Investigator, the DC Cohort Project Director, the Senior Deputy Director of the DC Department of Health HIV/AIDS, Hepatitis, STD and TB Administration, Dr. Henry Masur, and all DC Cohort Site PIs. Local site co-investigators may be added to the boilerplate at the discretion of the Executive Committee. This boilerplate may change over time as members leave or join the team; the Data and Statistics Coordinating Center (DSCC) will maintain an up-to-date, standard boilerplate for this purpose.

For all publications, the acknowledgement section should read the following:

Data in this manuscript were collected by the DC Cohort Study Group with investigators and research staff located at: Children's National Medical Center Adolescent (Lawrence D'Angelo) and Pediatric (Natella Rakhmanina) clinics; The Senior Deputy Director of the DC Department of Health HAHSTA (Michael Kharfen); Family and Medical Counseling Service (Michael Serlin); Georgetown University (Princy Kumar); The George Washington University Biostatistics Center (Aria Bamdad, Tsedenia Bezabeh, Susan Reamer, Alla Sapozhnikova, Marinella Temprosa, Naji Younes, Jinxi Liu and Kevin Xiao); The George Washington University Department of Epidemiology (Morgan Byrne, Amanda Castel, Alan Greenberg, Maria Jaurretche, Matthew Levy, Anne Monroe, James Peterson, Lindsey Powers Happ, Brittany Wilbourn) and Department of Biostatistics and Bioinformatics (Yan Ma); The George Washington University Medical Faculty Associates (Hana Akselrod); Howard University Adult Infectious Disease Clinic (Ronald Wilcox) and Pediatric Clinic (Sohail Rana); Kaiser Permanente Mid-Atlantic States (Michael Horberg); La Clinica Del Pueblo (Ricardo Fernandez); MetroHealth (Annick Hebou); National Institutes of Health (Carl Dieffenbach, Henry Masur); Washington Health Institute, formerly Providence Hospital (Jose Bordon); Unity Health Care (Gebeyehu Teferi); Veterans Affairs Medical Center (Debra Benator); Washington Hospital Center (Maria Elena Ruiz); and Whitman-Walker Health (Stephen Abbott).

The DC Cohort is funded by the National Institute of Allergy and Infectious Diseases, UM1 AI069503 and 1R24AI152598-01.

Publications

2020

Levy ME, Monroe AK, Horberg MA, Benator DA, Castel AD, DC Cohort Executive Committee. Is Low-Level Viraemia Associated with Serum Lipid Profiles among HIV Controllers? HIV Med. 2020 [In Press]

Levy ME, Ma Y, Magnus M, Younes N, Castel AD, DC Cohort Executive Committee. Cholesterol-Lowering Effect of Statin Therapy in a Clinical HIV Cohort: An Application of Double Propensity Score Adjustment. Ann Epidemiol. 2020. doi: https://doi.org/10.1016/j.annepidem.2020.02.005. (Link to manuscript)

Opoku J, Doshi RK, Castel AD, Sorensen I, Horberg M, Allston A, Kharfen M, Greenberg AE, DC Cohort Executive Committee. Comparison of Clinical Outcomes of Persons Living with HIV by Enrollment Status in a Large Longitudinal HIV Cohort Study, Washington, DC. JMIR Public Health Surveill. 2020. doi: 10.2196/preprints.16061. (Link to manuscript)

Levy ME, Griffith C, Ellenberger N, Monroe AK, Castel AD, Rakhmanina N, DC Cohort Executive Committee. Outcomes of Integrase Inhibitor-Based Antiretroviral Therapy in a Clinical Cohort of Treatment-Experienced Children, Adolescents and Young Adults with HIV Infection. Pediatr Infect Dis J. 2020. doi: 10.1097/INF.0000000000002577. (Link to manuscript)

Gibson KM, Bendall ML, Jair K, Jordan JA, Castel AD, Wilbourn B, Crandall KA, Pérez Losada M, DC Cohort Executive Committee. A Cross-Sectional Study to Characterize HIV-1 Dynamics in Washington DC Using Next-Generation Sequencing. Sci Rep. 2020; 10(1):1989. (Link to manuscript)

Secco AA, Akselrod H, Czeresnia J, Levy M, Byrne M, Monroe A, Lucar J, Horberg M, Castel AD, Doshi R, Rivasplata H, Squires L, Parenti D, Benator D, DC Cohort Executive Committee. Sexually Transmitted Infections in Persons Living with HIV Infection and Estimated HIV Transmission Risk: Trends Over Time from the DC Cohort. Sexually Transmitted Infections 2020. Epub 2020/01/06.doi:10.1136/sextrans-2019-054216. PubMed PMID: 31907326. (Link to manuscript

2019

Monroe AK, Powers Happ L, Rayeed N, Ma Y, Jaurretche MJ, Terzian AS, Trac K, Horberg MA, Greenberg AE, Castel AD, DC Cohort Executive Committee. Clinic-Level Factors Associated with Time to Antiretroviral Initiation and Viral Suppression in a Large Urban Cohort. Clinical Infectious Diseases 2019. Epub 2019/11/08.doi:10.1093/cid/ciz1098. PubMed PMID: 31701144. (Link to manuscript)

Doshi S, Ucanda M, Hart R, Hou Q, Terzian AS, DC Cohort Executive Committee. Incidence and Risk Factors for Renal Disease in an Outpatient Cohort of HIV-Infected Patients on Antiretroviral Therapy. Kidney International Reports 2019. Epub 2019/05/07. doi: 10.1016/j.ekir.2019.04.024.  PubMed PMID: 31440698. (Link to manuscript)

Jair K, McCann CD, Reed H, Castel AD, Perez-Losada M, Wilbourn B, Greenberg AE, Jordan JA, DC Cohort Executive Committee. Validation of Publicly-Available Software Used in Analyzing NGS Data for HIV-1 Drug Resistance Mutations and Transmission Networks in a Washington, DC, Cohort. PLoS One. 2019;14(4):e0214820. Epub 2019/04/09. doi: 10.1371/journal.pone.0214820. PubMed PMID: 30964884. (Link to manuscript)

Gibson KM, Steiner MC, Kassaye S, Maldarelli F, Grossman Z, Pérez-Losada M, Crandall KA. A 28-year History of HIV-1 Drug Resistance and Transmission in Washington, DC. Front. Microbiol. 2019. Epub 2019/03/08. doi: 10.3389/fmicb.2019.00369. PubMed PMID: 30906285. (Link to manuscript)

Levy ME, Greenberg AE, Magnus M, Younes N, Castel A. Immunosuppression and HIV Viremia Associated with More Atherogenic Lipid Profile in Older People with HIV. AIDS Research and Human Retroviruses 2019;35:81-91. Epub 2019/01/11. doi: 10.1089/AID.2018.0145. PubMed PMID: 30353737; PMCPMC6343189.(Link to manuscript)

Levy ME, Monroe AK, Horberg MA, Benator DA, Molock S, Doshi RK, Powers Happy L, Castel AD. Pharmacologic Treatment of Psychiatric Disorders and Time with Unsuppressed HIV Viral Load in a Clinical HIV Cohort.  J Acquir Immune Defic Syndr. 2019. Epub 2019/07/24. doi: 10.1097/QAI.0000000000002138. PubMed PMID: 31356466. (Link to manuscript

2018

Terzian A, Younes N, Greenberg AE, Opoku J, Hubbard J, Powers Happ L, Kumar P, Jones RR, Castel AD, DC Cohort Executive Committee. Identifying Spatial Variation Along the HIV Care Continuum: The Role of Distance to Care on Retention and Viral Suppression. AIDS Behav. 2018. Epub 2018/04/01. doi: 10.1007/s10461-018-2103-8. PubMed PMID: 29603112. (Link to manuscript)

Castel AD, Terzian A, Opoku J, Powers Happ L, Younes N, Kharfen M, Greenberg AE, DC Cohort Executive Committee. Defining Care Patterns and Outcomes Among Persons Living with HIV in Washington, DC: Linkage of Clinical Cohort and Surveillance Data. JMIR public health and surveillance. 2018;4(1):e23. Epub 2018/03/20. doi: 10.2196/publichealth.9221. PubMed PMID: 29549065; PMCPMC5878363. (Link to manuscript)

Lucar J, Hart R, Rayeed N, Terzian A, Weintrob A, Siegel M, Parenti DM, Squires LE, Williams R, Castel AD, Benator DA, DC Cohort Executive Committee. Sexually Transmitted Infections among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data from the DC Cohort. Open Forum Infectious Diseases. 2018;5(2):ofy017. Epub 2018/02/27. doi: 10.1093/ofid/ofy017. PubMed PMID: 29479550; PubMed Central PMCID: PMCPMC5804762. (Link to manuscript)

Levy ME, Greenberg AE, Magnus M, Younes N, Castel A. Evaluation of Statin Eligibility, Prescribing Practices, and Therapeutic Responses Using ATP III, ACC/AHA, and NLA Dyslipidemia Treatment Guidelines in a Large Urban Cohort of HIV-Infected Outpatients. AIDS Patient Care STDS. 2018;32(2):58-69. Epub 2018/03/22. doi: 10.1089/apc.2017.0304. PubMed PMID: 29561173; PubMed Central PMCID: PMCPMC5808384. (Link to manuscript)

2017

Pérez-Losada M, Castel AD, Lewis B, Kharfen M, Cartwright CP, Huang B, Maxwell T, Greenberg AE, Crandall KA, DC Cohort Executive Committee. Characterization of HIV Diversity, Phylodynamics and Drug Resistance in Washington, DC. PLoS One. 2017;12(9):e0185644. Epub 2017/09/30. doi: 10.1371/journal.pone.0185644. PubMed PMID: 28961263; PubMed Central PMCID: PMCPMC5621693. (Link to manuscript

Castel AD, Terzian A, Hart R, Rayeed N, Kalmin MM, Young HA, Greenberg AE, DC Cohort Executive Committee. Use of National Standards to Monitor HIV Care and Treatment in a High Prevalence City-Washington, DC. PLoS One. 2017;12(10):e0186036. Epub 2017/10/06. doi: 10.1371/journal.pone.0186036. PubMed PMID: 28982127; PubMed Central PMCID: PMCPMC5628915. (Link to manuscript)

Asamsama OH, Squires L, Tessema A, Rae E, Hall K, Williams R, Benator D. HIV Nurse Navigation: Charting the Course to Improve Engagement in Care and HIV Virologic Suppression. Journal of the International Association of Providers of AIDS Care. 2017;16(6):603-7. Epub 2017/10/12. doi: 10.1177/2325957417732835. PubMed PMID: 29017375. (Link to manuscript)

Aldous AM, Castel AD, Parenti DM, DC Cohort Executive Committee. Prevalence and Trends in Transmitted and Acquired Antiretroviral Drug Resistance, Washington, DC, 1999-2014. BMC Res Notes. 2017;10(1):474. Epub 2017/09/13. doi: 10.1186/s13104-017-2764-9. PubMed PMID: 28893321; PubMed Central PMCID: PMCPMC5594524. (Link to manuscript)

Levy ME, Greenberg AE, Hart R, Powers Happ L, Hadigan C, Castel AD, DC Cohort Executive Committee. High Burden of Metabolic Comorbidities in a Citywide Cohort of HIV Outpatients: Evolving Health Care Needs of People Aging with HIV in Washington, DC. HIV Med. 2017;18(10):724-35. Epub 2017/05/16. doi: 10.1111/hiv.12516. PubMed PMID: 28503912; PubMed Central PMCID: PMCPMC5643214. (Link to manuscript)

2016

Castel AD, Kalmin MM, Hart RL, Young HA, Hays H, Benator D, Kumar P, Elion R, Parenti D, Ruiz ME, Wood A, D'Angelo L, Rakhmanina N, Rana S, Bryant M, Hebou A, Fernández R, Abbott S, Peterson J, Wood K, Subramanian T, Binkley J, Happ LP, Kharfen M, Masur H, Greenberg AE. Disparities in Achieving and Sustaining Viral Suppression among a Large Cohort of HIV-Infected Persons in Care Washington, DC. AIDS Care. 2016;28(11):1355-64. Epub 2016/06/15. doi: 10.1080/09540121.2016.1189496. PubMed PMID: 27297952; PubMed Central PMCID: PMCPMC5084086. (Link to manuscript)

Rakhmanina N, Lam KS, Hern J, Young HA, Walters A, Castel AD. Interruptions of Antiretroviral Therapy in Children and Adolescents with HIV Infection in Clinical Practice: A Retrospective Cohort Study in the USA. J Int AIDS Soc. 2016;19(1):20936. Epub 2016/11/01. doi: 10.7448/ias.19.1.20936. PubMed PMID: 27797320; PubMed Central PMCID: PMCPMC5087211. (Link to manuscript)

Greenberg AE, Hays H, Castel AD, Subramanian T, Powers Happ L, Jaurretche M, Binkley J, Kalmin MM, Wood K, Hart R, DC Cohort Executive Committee. Development of a Large Urban Longitudinal HIV Clinical Cohort Using a Web-Based Platform to Merge Electronically and Manually Abstracted Data from Disparate Medical Record Systems: Technical Challenges and Innovative Solutions. Journal of the American Medical Informatics Association: JAMIA. 2016;23(3):635-43. Epub 2016/01/02. doi: 10.1093/jamia/ocv176. PubMed PMID: 26721732; PubMed Central PMCID: PMCPMC4901378. (Link to manuscript)

PRESENTATIONS AT SCIENTIFIC CONFERENCES

2020

Elf JL, Horn K, Abroms L, Stanton C, Cohn A, Spielberg F, Gray T, Harvey E, Sanchez D, Debnam C, Castel AD, Greenberg A, Monroe A, Niaura R, on behalf of the DC Cohort Executive Committee. “Cigarette smoking among HIV-infected adults with comorbid medical conditions in a large HIV cohort (2011-2017) in Washington, D.C.” Poster presentation at the Society for Research on Nicotine and Tobacco, New Orleans LA, March 2020. (Poster PDF)

Akselrod H, Byrne B, Monroe AK, Levy ME, Denyer R, Klein A, Horberg MA, Castel AD, Doshi RK, Secco A, Lucar J, Squires L, Schroeter S, Benator DA. "Geographic Estimate of Sexual HIV Transmission Burden in Era of U=U: DC Cohort Data." (Poster 1133),Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Boston MA, March 2020.(Poster PDF

Byrne M, Monroe AK, Powers Happ LJ, Doshi RK, Horberg MA, Castel AD. “Latent Class Analysis of Substance Use and HIV VL Trajectory Patterns among PWH in DC.” (Poster 891), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Boston MA, March 2020.(Poster PDF

Dirajlal-Fargo S, Koay WLA, Levy ME, Monroe AK, CastelAD, Rakhmanina N. "Effect of Integrase Inhibitors on Weight Gain in Children and Adolescents." (Poster 0826), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Boston MA, March 2020. (Poster PDF)

2019

Jaurretche M, Byrne M, Powers Happ L, Levy ME, Horberg MA, Greenberg AE, Castel AD, Monroe AK, on behalf of the DC Cohort Executive Committee. “HIV Care Continuum Outcomes among Newly Diagnosed PLWH in Washington, DC.” (Poster 1320), Poster Presentation at IDWeek 2019, Washington DC, October 2019. (Poster PDF

Monroe AK, Levy ME, Greenberg AE, Moore RD, Keruly JC, Horberg MA, Mohanraj S, Kumar P, Castel AD, on behalf of the DC Cohort Executive Committee. “Differences Between Individuals Currently Taking Integrase Inhibitor (INSTI)-Based Therapy and Those Not Taking INSTIs in the Era of INSTIs as Recommended First-Line Therapy.” (Poster 2492), Poster Presentation at IDWeek 2019, Washington DC, October 2019. (Poster PDF)

Powers Happ L, Monroe AK, Young HA, Ma Y, Greenberg AE, Benator DA, Horberg MA, Castel A, on behalf of the DC Cohort Executive Committee. “The Impact of Glycemic Control on CD4 Cell Count in Persons Living with HIV and Diabetes Mellitus—Washington, DC.” (Poster 342), Poster Presentation at IDWeek 2019, Washington DC, October 2019. (Poster PDF

Akselrod H, Secco A, Lucar J, Levy M, Byrne M, Monroe AK, Horberg MA, Castel AD, Doshi RK, Rivasplata H, Squires L, Parenti D, Benator DA, on behalf of the DC Cohort Executive Committee. “Incident STIs among PLWH in Washington, DC: Measuring HIV Transmission Risk.” (Poster 849), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, March 2019. (Poster PDF)  

Doshi R, Byrne M, Levy M, Varga L, Kuo I, Horberg MA, Castel AD, Monroe AK, on behalf of the DC Cohort Executive Committee. “Substance Use Disorders Associated with Mortality Among HIV+ In Washington, DC.” (Poster 880), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, March 2019. (Poster PDF)

Kuriakose S, George J, Monroe AK, Hou Q, Pau AK, Masur H, Hadigan C, Castel AD, Horberg MA, on behalf of the DC Cohort Executive Committee. “Direct Oral Anticoagulant and ART Usage in PLWH: Data from the DC Cohort.” (Poster 641), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, March 2019. (Poster PDF)

Opoku J, Castel AD, Doshi R, Allston A, Greenberg AE, Kharfen M, on behalf of the DC Cohort Executive Committee. “Comparing Clinical Outcomes of Persons Living with HIV Who Have and Have Not Been Enrolled in a Large Longitudinal HIV Cohort Study in Washington, DC.” (Poster 6014), Poster Presentation at the National HIV Prevention Conference, Atlanta GA, March 2019. (Poster PDF)

Levy M, Monroe AK, Horberg MA, Benator DA, Molock S, Doshi RK, Powers Happ L, Castel AD, on behalf of the DC Cohort Executive Committee. “Treatment of Psychiatric Disorders and Time with HIV Viral Load > 200 copies/mL.” (Poster 700), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, March 2019. (Poster PDF)

Mohanraj SB, Hou Q, Monroe AK, Kassaye S, on behalf of the DC Cohort Executive Committee. “Six Years of Integrase Inhibitor Use in a Metropolitan City.” (Poster 0906), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, March 2019. (Poster PDF)

Spence AB, Levy ME, Monroe AK, Timpone J, Castel AD, Horberg MA, Kumar K, on behalf of the DC Cohort Executive Committee. “Cancer Incidence Among a Cohort of Persons Receiving HIV Care in Washington, DC.” (Poster 290), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, March 2019. (Poster PDF

Castel AD, Wilbourn B, Wertheim JO, Jordan JA, Jair K, Greenberg AE, on behalf of the DC Cohort Executive Committee. “Detection and Characterization of HIV Clusters Using HIV-TRACE among a Cohort of Persons Living with HIV in Washington, DC.” National HIV Prevention Conference (NHPC), Atlanta GA, 2019. (Poster PDF)

2018

Secco A, Akselrod H, Lucar J, Rayeed N, Leighton N, Parenti D, Benator DA on behalf of the DC Cohort Executive Committee. “Sexually Transmitted Infections among Persons Living with HIV Infection and Receiving Care in the District of Columbia: Time with Viral Load above 1500 as Proxy for Risk of Transmission.” (Poster 1498), Poster Presentation at Infectious Disease Society of America (IDSA), San Francisco CA, 2018. (Poster PDF)

George JM, Kuriakose SS, Monroe AK, Hou Q, Pau AK, Masur H, Hadiagan C, Castel AD, Horberg MA on behalf of the DC Cohort Executive Committee. “Increasing Utilization of Direct Oral Anticoagulants (DOACs) and Drug Interaction in People Living with HIV on Antiretroviral Therapy (ART): Data from the DC Cohort.” Poster Presentation at the 20th International Workshop on Co-Morbidities and Adverse Drug Reactions in HIV, New York NY, 2018. (Poster PDF)

Levy ME, Greenberg AE, Magnus M, Younes N, Castel AD, on behalf of the DC Cohort Executive Committee. “Immunosuppression and HIV Viremia Associated with Increased Atherogenic Cholesterol Concentrations in Older People with HIV.” (Poster TUPEB125), Poster Presentation at the XXII International AIDS Conference, Amsterdam Netherlands, July 2018. (Poster PDF)

Rakhmanina N, Levy ME, Ellenberger N, Griffith C, Monroe AK, Castel AD, on behalf of the DC Cohort Executive Committee. “Outcomes of Integrase Inhibitor-Based ART in Treatment-Experienced Children, Adolescents and Young Adults with HIV Infection.” (Poster 37), Poster Presentation at the 10th Workshop on HIV Pediatrics, Amsterdam Netherlands, July 2018. (Poster PDF)

Wilbourn BC, Greenberg AE, Kassaye S, Parenti D, Serlin M, Goldstein D, Hardy D, Teferi G, Hebou A, Benator D, Kumar P, Fernandez R, Bordon J, Castel AD, on behalf of the DC Cohort Executive Committee. “Behaviors Associated with Ongoing Transmission Risk among Recently Diagnosed and Chronically-Infected Persons Living with HIV in Washington, DC.” (Poster 179), Poster Presentation at the International Conference on HIV Treatment and Prevention Adherence, Miami FL, June 2018. (Poster PDF)

Castel AD, Powers Happ L, Monroe A, Jaurretche M, Terzian A, Greenberg AE on behalf of the DC Cohort Executive Committee. “Individual and Site-Level Factors Associated with Risk of Death among People with HIV.” (Poster 892), Poster Presentation at Conference on Retroviruses and Opportunistic Infections, Boston MA, February 2018. (Poster PDF)

Levy ME, Greenberg AE, Magnus M, Younes N, Castel AD, on behalf of the DC Cohort Executive Committee. “Statin Coverage in an HIV Cohort: Comparison of ATP III, ACC/AHA, and NLA Guidelines.” (Poster 690), Poster Presentation at Conference on Retroviruses and Opportunistic Infections, Boston MA, February 2018. (Poster PDF)

Monroe AK, Rayeed N, Jaurretche M, Powers Happ L, Trac K, Terzian A, Greenberg AE, Castel AD, on behalf of the DC Cohort Executive Committee. “Clinic-Level Factors Associated with Time to Viral Suppression in Washington, DC.” (Poster 1123), Poster Presentation at Conference on Retroviruses and Opportunistic Infections, Boston MA, February 2018. (Poster PDF) 

2017

Kalmin MM, Greenberg AE, Castel AD, Young H, Hoffman HJ, on behalf of the DC Cohort Executive Committee. “Association between Four Measures of Retention in Care and Virologic Failure.” (Poster 1503), Poster Presentation at Conference on Retroviruses and Opportunistic Infections, Seattle WA, February 2017. (Poster PDF)

Terzian A, Younes N, Opoku J, Hubbard J, Jones RR , Kumar P, Castel AD, on behalf of the DC Cohort Executive Committee. “Spatial Variation along the HIV Care Continuum in Washington, DC 2014-2015.” (Poster 905), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, February 2017. (Poster PDF)

2016

Levy ME, Greenberg AE, Hart RD, Powers Happ L, Hadigan C, Castel AD, on behalf of the DC Cohort Executive Committee. “High Burden of Metabolic Comorbidities in a Citywide Cohort of HIV Outpatients: Evolving Health Care Needs of People Aging with HIV in Washington, DC.” (Oral Presentation 06), Oral Presentation at the 7th International Workshop on HIV and Aging, Washington DC, September 2016 (Oral Presentation).

2015

Castel AD, Kalmin MM, Hart RD, Greenberg AE, Masur H, on behalf of the DC Cohort Executive Committee. “Identifying and Prioritizing Hepatitis C Treatment for HIV-Hepatitis C Co-Infection.” (Poster 660), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Seattle WA, February 2015. (Poster PDF)

Asamsama OH, Tessema A, Squires LE, Hall K, Benator DA. “HIV Nurse Navigation: Charting the Course to Improve Retention in Care and HIV Virologic Suppression.” Poster Presentation at The American Conference for the Treatment of HIV (ACTHIV), Dallas TX, April-May 2015. (Poster PDF)

Teran R, Balamane M, Nigam N, Umans J, Timpone J, Kumar P, Kassaye S. “Chronic Kidney Disease among HIV and HIV/HCV Co-Infected Individuals in Washington, DC.” Abstract Presentation at Kidney Week, San Diego CA, November 2015. (Poster PDF).

Ucanda M, Hart RD, Gajjala J, Doshi S, on behalf of the DC Cohort Executive Committee. “Examining the Risk for Acute Kidney Injury in HIV-Infected Adults Concurrently using Diuretics and Tenofovir Disoproxil Fumarate in Washington, DC Clinics.” (Poster 1654), Poster Presentation at the Infectious Disease Society of America (IDSA), San Diego CA, October 2015. (Poster PDF).

Lucar J, Hart RD, Weintrob A, Siegel M, Parenti D, Benator DA, for the DC Cohort Executive Committee.Sexually Transmitted Infections among HIV Infected Patients Receiving Care in the District of Columbia: Incidence and Correlates of Syphilis, Gonorrhea, Chlamydia and Viral Hepatitis in the DC Cohort.” (Poster 1697), Poster Presentation at the Infectious Disease Society of America (ISDA), San Diego CA, October 2015. (Poster PDF).

Aldous AM, Castel AD, Parenti DM, on behalf of the DC Cohort Executive Committee. “Prevalence and Trends in Transmitted and Acquired Antiretroviral Drug Resistance in Washington, DC, 1999-2014.” (Poster 387), Poster Presentation at the Infectious Disease Society of America (ISDA), San Diego CA, October 2015. (Poster PDF)

Castel AD, Opoku J, Powers Happ L, Kharfen M, Greenberg AE, Younes N, on behalf of the DC Cohort Executive Committee. “Increasing the Completeness of HIV Public Health Surveillance and Clinical Research Databases: Linkage of District of Columbia Surveillance Data with DC Cohort Study Data-Washington, DC.” (Poster 2306), Poster Presentation at the CDC’s National HIV Prevention Conference, Atlanta GA, December 2015. (Poster PDF)

Balamane M, Teran R, Timpone J, Umans JG, Kumar P, Kassaye S. “HCV Independently Affects Kidney Function among HIV Co-Infected Individuals.” Abstract Presentation at Kidney Week, San Diego CA, November 2015. (Abstract PDF)

2014

Castel AD, Greenberg AE, Young HA, Kalmin MM, on behalf of the DC Cohort Executive Committee. “Disparities in Viral Suppression among a Large Cohort of HIV-Infected Persons in Washington, DC.” (Poster 993), Poster Presentation at Conference on Retroviruses and Opportunistic Infections, Boston MA, March 2014. (Poster PDF)

Castel AD, Greenberg AE, Kalmin MM, Young HA, on behalf of the DC Cohort Executive Committee. “Use of National Standards to Monitor HIV Care and Treatment in a High Prevalence City – Washington, DC.” (Poster 998), Poster Presentation at the Conference on Retroviruses and Opportunistic Infections, Boston MA, March 2014. (Poster PDF

2012

Castel AD, on behalf of the DC Cohort Executive Committee. “Implementation of a City-Wide Cohort of HIV-Infected Persons in Care in Washington DC: The DC Cohort.” (DC #A-452-0146-08025), Poster Presentation at The International AIDS Conference, Washington DC, July 2012. (Poster PDF)

2019

Monroe AK, Powers Happ L, Rayeed N, Ma Y, Jaurretche MJ, Terzian AS, Trac K, Horberg MA, Greenberg AE, Castel AD, DC Cohort Executive Committee. Clinic-level factors associated with time to antiretroviral initiation and viral suppression in a large urban cohort. Clinical Infectious Diseases 2019. Epub 2019/11/08.doi:10.1093/cid/ciz1098. PubMed PMID: 31701144. (Link to manuscript)

Doshi S, Ucanda M, Hart R, Hou Q, Terzian AS, DC Cohort Executive Committee. Incidence and Risk Factors for Renal Disease in an Outpatient Cohort of HIV-Infected Patients on Antiretroviral Therapy. Kidney International Reports 2019. Epub 2019/05/07. doi: 10.1016/j.ekir.2019.04.024.  PubMed PMID: 31440698. (Link to manuscript)

Jair K, McCann CD, Reed H, Castel AD, Perez-Losada M, Wilbourn B, Greenberg AE, Jordan JA, DC Cohort Executive Committee. Validation of Publicly-Available Software Used in Analyzing NGS Data for HIV-1 Drug Resistance Mutations and Transmission Networks in a Washington, DC, Cohort. PLoS One. 2019;14(4):e0214820. Epub 2019/04/09. doi: 10.1371/journal.pone.0214820. PubMed PMID: 30964884. (Link to manuscript)

Gibson KM, Steiner MC, Kassaye S, Maldarelli F, Grossman Z, Pérez-Losada M, Crandall KA. A 28-year History of HIV-1 Drug Resistance and Transmission in Washington, DC. Front. Microbiol. 2019. Epub 2019/03/08. doi: 10.3389/fmicb.2019.00369. PubMed PMID: 30906285. (Link to manuscript)

Levy ME, Greenberg AE, Magnus M, Younes N, Castel A. Immunosuppression and HIV Viremia Associated with More Atherogenic Lipid Profile in Older People with HIV. AIDS Research and Human Retroviruses 2019;35:81-91. Epub 2019/01/11. doi: 10.1089/AID.2018.0145. PubMed PMID: 30353737; PMCPMC6343189.(Link to manuscript)

Levy ME, Monroe AK, Horberg MA, Benator DA, Molock S, Doshi RK, Powers Happy L, Castel AD. Pharmacologic Treatment of Psychiatric Disorders and Time with Unsuppressed HIV Viral Load in a Clinical HIV Cohort.  J Acquir Immune Defic Syndr. 2019. Epub 2019/07/24. doi: 10.1097/QAI.0000000000002138. PubMed PMID: 31356466. (Link to manuscript

Data Sharing Information

Data Analysis and Collaboration

Welcome to the DC Cohort Data Analysis and Collaboration site. The DC Cohort endeavors to collaborate with authorized internal and external users of the data to allow for a broad spectrum of data and research purposes.

Who is authorized to use DC Cohort data?

  • DC Cohort Site Principal Investigators (PIs)
  • Staff or fellows at a participating DC Cohort site
    • Must be sponsored by a DC Cohort Site PI
  • Members of the DC Cohort Data and Statistics Coordinating Center (DSCC)
  • Members of the DC Center for AIDS Research (CFAR)
    • After discussion with the DC Cohort Site PI
  • GWU staff
    • Must be sponsored by a DC Cohort staff member
  • GWU students
    • Must be sponsored by a DC Cohort GWU faculty member
    • Must utilize the data for the purposes of meeting educational research requirements, i.e. Master’s theses or Doctoral dissertations
  • Outside investigators who are sponsored by a DC Cohort Site PI or an authorized member of the DSCC.

Collaboration Process-Cohort-Wide Analysis

  1. Read the Collaboration Policies document. This document outlines the policies and procedures for obtaining, using, and publishing with DC Cohort data.
  2. Complete a Concept Sheet and Data Request Form. These documents succinctly outline the data needed to complete your analysis. If you are requesting analytic support, you must indicate this here. Completed forms should be submitted via e-mail to Dr. Amanda Castel at acastel@gwu.edu. Data sent to external requesters may be subject to de-identification and some data elements may not be available for such requests. Please see the Data Request Form for any limitations on data requests.
  3. The Concept Sheet and Data Request Form will undergo three separate, concurrent reviews. They are reviewed by the DC Cohort PI or her designee, members of the DSCC, and by a DSCC analyst for data availability and feasibility. This process may involve additional questions and/or requests for revisions prior to approval. Once finalized, all cohort-wide analyses are reviewed, approved, and prioritized by the DC Cohort. On average, this process can take 4-6 weeks from concept sheet submission to approval.
  4. Once approved, if you have requested analytic support, then you will be put in touch with the analyst assigned to your project and can begin regular communications to move forward with your analysis.
  5. If you have not requested analytic support, then you will need to complete a Data Use Agreement and Data Management Plan. The DSCC will create custom data sets fit to the specifications detailed in your Data Request Form. These will be sent to you along with accompanying documentation as soon as they are available.
    1. Please note that once the concept sheet is approved, it takes approximately 4-6 weeks to receive the data.

Collaboration Process-Site-Specific Analysis

  1. Read the Collaboration Policies document. This document outlines the policies and procedures for obtaining, using, and publishing with DC Cohort data.
  2. Complete a Concept Sheet and Data Request Form. These documents succinctly outline the data needed to complete your analysis. If you are requesting analytic support, you must indicate this here. Completed forms should be submitted via e-mail to Dr. Amanda Castel at acastel@gwu.edu. Data sent to external requesters may be subject to de-identification and some data elements may not be available for such requests. Please see the Data Request Form for any limitations on data requests.
  3. The Concept Sheet and Data Request Form will undergo two separate, concurrent reviews. They are reviewed by the DC Cohort PI or her designee for clinical relevance, and by a DSCC analyst for data availability and feasibility. This process may involve additional questions and/or requests for revisions prior to approval. Once finalized, site-specific analyses are forwarded to the Executive Committee for their awareness.  On average, this process can take 4-6 weeks from concept sheet submission to approval.
  4. Once approved, if you have requested analytic support, then you will be put in touch with the analyst assigned to your project and can begin regular communications to move forward with your analysis. Please note, due to limited resources, cohort-wide analysis will have prioritization for analytic support from the DSCC.
  5. If you have not requested analytic support, then you will need to complete a Data Use Agreement and Data Management Plan. The DSCC will create custom data sets fit to the specifications detailed in your Data Request Form. These will be sent to you along with accompanying documentation as soon as they are available.
    1. Please note that once the concept sheet is approved, it takes approximately 4-6 weeks to receive the data.

Ad Hoc Requests for Internal Purposes

For internal requests such as grant proposals, clinical trials, etc. that involve site-specific data and can be confined to a count or list of available participants, an email request can be sent to Amanda Castel at acastel@gwu.email.edu. If it is determined that the request is lengthy in nature or rises to the level of an analysis, then it may be determined that a concept sheet and data request form may be required following the processes described above.

Publication

In order to ensure that all products meet the standards and specifications of the DC Cohort, prior to submission to either a journal, meeting, conference, etc., your final product must undergo a review process. E-mail your final draft to Amanda Castel at acastel@gwu.edu along with all accompanying analytic code and your completed Data Analysis Plan. The DC Cohort Executive Committee reviews all abstracts, manuscripts, posters, etc., provides feedback to the authors, and approves final versions of cohort-wide analyses. Additionally, all analytic code for any analysis is reviewed by the DSCC. This process takes approximately 2-4 weeks, so please plan accordingly to allow sufficient time for review and approval prior to any submission deadlines.

The DC Cohort must be cited in all works. For manuscripts, the author line must end “on behalf of the DC Cohort Executive Committee.” Additionally, an acknowledgement section must list all participating DC Cohort members; click here for an updated acknowledgement list.

Newsletter

The DC Cohort team is pleased to announce the first edition of the study newsletter that is now published and available for viewing. In the March 2020 edition, we have highlighted research updates from 2019 including posters presented at scientific conferences and a recent publication in a peer-review journal. All DC Cohort posters and publications can be accessed on the Publications page on this website.

Click here to access the newsletter.

About

Clinical Sites

The focus of the DC Cohort is on the major publicly-funded, government and academic medical center HIV clinics, with consideration of other clinics and large private practices at a later date. The institutions involved include:

Data and Statistics Coordinating Center

The George Washington University (GWU) Department of Epidemiology and the GWU Biostatistics Center (BSC) together form the DC Cohort Data and Statistics Coordinating Center (DSCC). The DSCC is responsible for management and analysis of data for the DC Cohort.

Executive Committee

The DC Cohort Executive Committee (EC) coordinates the overall direction of the study in conjunction with the Partnership for AIDS Progress (PFAP) Executive Committee.

The DC Cohort EC members include:

Executive Committee Members

Name Title
Amanda D. Castel, M.D., M.P.H. D.C. Cohort Principal Investigator, The Milken Institute School of Public Health
Alan E. Greenberg, M.D., M.P.H. D.C. Cohort Senior Co-Investigator, The Milken Institute School of Public Health
Anne Monroe, M.D., M.S.P.H. D.C. Cohort Project Director, The Milken Institute School of Public Health
Carl W. Dieffenbach, Ph.D. Director, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Henry Masur, M.D. Chief, Critical Care Medicine Department, Clinical Center, National Institutes of Health
Michael Kharfen Senior Deputy Director, D.C. Department of Health HIV/AIDS, Hepatitis, STD, TB Administration
Debra Benator, M.D. Site Principal Investigator, Veterans Affairs Medical Center
Jose Bordon, M.D., Ph.D. Site Principal Investigator, Washington Health Institute (formerly Providence Hospital)
Lawrence J. D'Angelo, M.D., M.P.H. Site Principal Investigator, Children's National Medical Center (Adolescent Clinic)
Ricardo Fernandez, M.D. Site Principal Investigator, La Clinica Del Pueblo
Stephen Abbott, M.D. Site Principal Investigator, Whitman-Walker Health
Annick Hebou, M.D. Site Principal Investigator, MetroHealth
Michael Horberg, M.D. Site Principal Investigator, Kaiser Permanente Mid-Atlantic States
Princy N. Kumar, M.D. Site Principal Investigator, Georgetown University
Hana Akselrod, M.D., M.P.H. Site Principal Investigator, The George Washington University Medical Faculty Associates
Natella Rakhmanina, M.D., Ph.D. Site Principal Investigator, Children's National Medical Center (Pediatric Clinic)
Sohail Rana, M.D. Site Principal Investigator, Howard University Hospital (Pediatric Clinic)
Maria Elena Ruiz, M.D. Site Principal Investigator, Washington Hospital Center
Gebeyehu Teferi, M.D. Site Principal Investigator, Unity Health Care
Ronald Wilcox, M.D. Site Principal Investigator, Howard University Hospital (Adult Infectious Disease Clinic)
Michael Serlin, M.D. Site Principal Investigator, Family Medical and Counseling Service

Contact

General Inquiries 
Maria Jaurretche
DC Cohort Senior Research Coordinator
mjau@gwu.edu
 
Community Outreach Inquiries
James Peterson
DC Cohort Community Activities Coordinator
jpeterso@gwu.edu